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DNA, 75-87.

[33] 1. Tabansky, A. Lenarcic, R. W. Draft, K. Loulier, D. B. Keskin, J. Rosains, J. Rivera-Feliciano, J. W. Lichtman, J. Livet, J. N. Stern, J. R. Sanes, K. Eggan. Developmental Bias in Cleavage-Stage Mouse Blastomeres. Current Biology 23 (2013): 21-31. Doi: 10.1016/j cub.2012.10.054.

[34] Ibid.

Глава 6. Вскрытие черного ящика

[1] J. W. Lichtman, S. E. Fraser. The Neuronal Naturalist: Watching Neurons in Their Native Habitat. Nature Neuroscience 4 (2001): 1215-1220. Doi:10.1038/nn754.

[2] Insoo Hyun, Amy Wilkerson, Josephine Johnston. Embryology Policy: Revisit the 14-Day Rule. Nature 533 (2016): 169-171. URL: www. nature.com/news/embryology-policy-revisitthe- 14-day-rule-1.19838.

[3] J. Carver, К. Martin, I. Spyropoulou, D. Barlow, I. Sargent, H. Mar-don. An In-Vitro Model for Stromal Invasion During Implantation of the Human Blastocyst. Human Reproduction 18 (2003): 283-290.

[4] William Richard Rice. The High Abortion Cost of Human Reproduction. bioRxiv (2018): 372193.

[5] A. T. Hertig, J. Rock, E. C. Adams. A Description of 34 Human Ova Within the First 17 Days of Development. American Journal of Anatomy 98. No. 31 (1956): 435-493. URL: https://doi.org/10.1002/ aja. 1000980306.

[6] Ibid.

[7] B. Fu, Y. Zhou, X. Ni, X. Tong, X. Xu, Z. Dong, R. Sun, Z. Tian, H. Wei. Natural Killer Cells Promote Fetal Development Through the Secretion of Growth-Promoting Factors. Immunity 47 (2017): 1100-1113. Doi: 10.1016/j.immuni.2017.11.018.

[8] R. Vento-Tormo, M. Efremova, R. A. Botting, M. Y. Turco, M. Ven-to-Tormo, К. B. Meyer, J. E. Park, E. Stephenson, K. Polaski, A. Goncalves, L. Gardner, S. Holmqvist, J. Henriksson, A. Zou, A. M. Sharkey, B. Millar, B. Innes, L. Wood, A. Wilbrey-Clark, R. P. Payne, M. A. Ivarsson, S. Lisgo, A. Filby, D. H. Rowitch, J. N. Bulmer, G. J. Wright, M. J. T. Stubbington, M. Haniffa, A. Moffett, S. A. Teichmann. Single-Cell Reconstruction of the Early Maternal-Fetal Interface in Humans. Nature 563 (2018): 347-353. Doi: 10.1038/s41586-018-0698-6.

[9] F. Louwen, C. Muschol-Steinmetz, J. Reinhard, A. Reitter, J. Yuan. A Lesson for Cancer Research: Placental Microarray Gene Analysis in Preeclampsia. Oncotarget 3. No. 8 (2012): 759-773. Doi: 10.18632/ oncotarget.595.

[10] P. Thomas, R. Beddington. Anterior Primitive Endoderm May Be Responsible for Patterning the Anterior Neural Plate in the Mouse Embryo. Current Biology 11 (1996): 1487—1496.

[11] S. A. Morris, S. Grewal, F. Barrios, S. N. Patankar, B. Strauss, L. Buttery, M. Alexander, К. M. Shakesheff, M. Zernicka-Goetz. Dynamics of Anterior-Posterior Axis Formation in the Developing Mouse Embryo. Nature Communications 3 (2012): 673. Doi:10.1038/ncommsl671.

[12] Ibid.

[13] I. Bedzhov, М. Zernicka-Goetz. Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation. Cell 156 (2014): 1032-1044. Doi: 10.1016/j.cell.2014.01.023.

[14] A. Deglincerti, G. F. Croft, L. N. Pietila, M. Zernicka-Goetz, E. D. Siggia, A. H. Brivanlou. Self-Organization of the In Vitro Attached Human Embryo. Nature 533. No. 7602 (2016): 251—254. Doi:10.1038/ naturel7948; M. N. Shahbazi, A. Jedrusik, S. Vuoristo, G. Recher, A. Hupalowska, V. Bolton, N. N. M. Fogarty, A. Campbell, L. Devito, D. Ilic, Y. Khalaf, К. K. Niakan, S. Fishel, M. Zernicka-Goetz. Self-Organization of the Human Embryo in the Absence of Maternal Tissues. Nature Cell Biology 18. No. 6 (2016): 700-708. Doi:10.1038/ncb3347.

[15] H. Suryawanshi, P. Morozov, A. Straus, N. Sahasrabudhe, К. E. A. Max, A. Garzia, M. Kustagi, T. Tuschl, Z. Williams. A Single-Cell Survey of the Human First-Trimester Placenta and Eecidua. Science Advances 4 (2018): eaau4788. Doi: 10.1126/sciadv.aau4788.

[16] M. N. Shahbazi, A. Scialdone, N. Skorupska, A. Weberling, G. Recher, M. Zhu, A. Jedrusik, L. G. Devito, L. Noli, I. C. Macaulay, C. Buecker, Y. Khalaf, D. Ilic, T. Voet, J. C. Marioni, M. Zernicka-Goetz. Pluripotent State Transitions Coordinate Morphogenesis in Mouse and Human Embryos. Nature 552 (2017): 239—243. Doi:10.1038/nature24675.

Глава 7. Надо ли использовать в исследованиях человеческие эмбрионы?

[1] Cambridge Study Named as People’s Choice for Science Magazine’s Breakthrough of the Year 2016. University of Cambridge, accessed April 4, 2019. URL: www.cam.ac.uk/research/news/cambridge-study-named-as-peoples-choice-for-science-agazines-breakthrough-of-the-year-2016. v

[2] Human Embryo Culture. Nuffield Foundation for Bioethics, August 2017. URL: http://nuffieldbioethics.org/wp-content/uploads/ Human-Embryo-Culture-web-FlNAL.pdf.

[3] John Paul II encyclical, n.d., John Paul II website, accessed April 4, 2019. URL: http://w2.vatican.va/content/john-paul-ii/en/ encyclicals/documents/hfJp-ii_enc_25031995_evangeliumvitae. html#%241N.

[4] J. Rossant, P. P. L. Tam. Exploring Early Human Embryo Development. Science 360 (2018): 1075—1076. Doi: 10.1126/science.aas9302.

[5] John Rock, Miriam F. Menkin. In Vitro Fertilization and Cleavage of Human Ovarian Eggs. Science 100 (1944): 105—107. Doi: 10.1126/ science. 100.2588.105.

[6] Roy O. Greep. Min Chueh Chang 1908—1991: A Biographical Memoir. Washington, DC: National Academies Press, 1995. URL: www. nasonline.org/publications/biographical-memoirs/memoir-pdfs/ chang-m-c.pdf.

[7] R. G. Edwards. Meiosisin Ovarian Oocytes of Adult Mammals. Nature 196 (1962): 446-450.

[8] Martin H. Johnson, Carol Ann Ziomek. The Foundation of Two Distinct Cell Lineages Within the Mouse Morula. Cell 24. No. 1 (1981): 245-262. Doi.org/10.1016/0092-8674(81 )90502-X.

[9] Ibid.

[10] R. G Edwards, B. D. Bavister, P. C. Steptoe. Early Stages of Fertilization In Vitro of Human Oocytes Matured In Vitro. Nature 221 (1969): 632-635.

[11] R. G. Edwards, D. J. Sharpe. Social Values and Research in Human Embryology. Nature 231 (1971): 87-91.

[12] Monash University IVF History, accessed April 4,2019. URL: https:// monashivf.com/about-us/history/.

[13] Martin H. Johnson, Sarah B. Franklin, Matthew Cottingham, Nick Hopwood. Why the Medical Research Council Refused Robert Edwards and Patrick Steptoe Support for Research on Human Conception in 1971. Human Reproduction 25. No. 9 (2010): 2157—2174. Doi:10.1093/ humrep/deql55.

[14] A. Lopata, I. W. Johnston, I. J. Hoult, A. I. Speirs. Pregnancy Following Intrauterine Implantation of an Embryo Obtained by In Vitro Fertilization of a Preovulatory Egg. Fertility and Sterility 33. No.2(1980): 117-120.

[15] John Webster, email to Roger Highfield, February 24, 2019; Louise Brown. Louise Brown: 40 Years of IVF. Bristol, UK: Bristol Books, 2015,32; Duncan Wilson. The Making of British Bioethics. Manchester, UK: Manchester University Press, 2014, 152.

[16] Johnson et al. Why the Medical Research Council Refused, 2157—2174.

[17] Wilson. The Making of British Bioethics, 152.

[18] M. H. Johnson, K. Elder. The Oldham Notebooks: An Analysis of the Development of IVF 1969—1978. V. The Role of Jean Purdy Reassessed. Reproductive Biomedicine and Society Online 1 (2015): 46—57. Doi: 10.1016/j.rbms.2015.04.005; M. H. Johnson. IVF: The Women Who Helped Make It Happen. Reproductive